Cholinergic modulation of the sleep state-dependent P13 midlatency auditory evoked potential in the rat.
نویسندگان
چکیده
Injections into the pedunculopontine nucleus (PPN) of the cholinergic receptor agonist, carbachol (CAR), were found to reduce the amplitude of the vertex-recorded, sleep state-dependent P13 midlatency evoked potential in a dose- and time-dependent manner. This effect was blocked or reduced by pretreatment with the muscarinic receptor antagonist, scopolamine, injected into the PPN.
منابع مشابه
Effect of age on sensory gating of the sleep state-dependent P1/P50 midlatency auditory evoked potential.
The P1/P50 midlatency auditory evoked potential is a sleep state-dependent waveform present during waking and rapid eye movement (REM) sleep and absent during slow-wave sleep. The P50 potential was studied in normal male and female subjects of various ages including post-pubertal adolescents (12-19 yrs), young adults (24-39 yrs), middle-aged adults (40-55 yrs) and older adults (55-78 yrs). Ther...
متن کاملAuditory Evoked Potentials from Cortex, Thalamus and Inferior Colliculus during Sleep-wake States and Spike-wave Discharges in the Rat
The electrical brain activity during slow wave sleep is characterized by synchronized neocortical EEG activity, while active wakefulness and REM sleep are associated with a desynchronized EEG. It is a common finding that the amplitude of the visual evoked potential (VEP) in the rat is enlarged during EEG-synchronized states such as slow wave sleep and neocortical spike-wave discharges (Van Hulz...
متن کاملDisinhibition of the sleep state-dependent p1 potential in Parkinson's disease-improvement after pallidotomy.
We previously reported that the P1 or P50 midlatency evoked potential underwent decreased habituation or disinhibition in patients with Parkinson's Disease. This sleep state-dependent response appears to be generated by cholinergic elements of the reticular activating system. We attempted to determine if the decreased habituation or disinhibition of the P1 potential would be altered by bilatera...
متن کاملSmoking during pregnancy: postnatal effects on arousal and attentional brain systems.
Prenatal exposure to cigarette smoke is known to produce lasting arousal, attentional and cognitive deficits in humans. The pedunculopontine nucleus (PPN), as the cholinergic arm of the reticular activating system (RAS), is known to modulate arousal, waking and REM sleep. Rapid eye movement (REM) sleep decreases between 10 and 30 days postnatally in the rat, with the greatest decrease occurring...
متن کاملEffects of Glutamate Receptor Agonists on the P13 Auditory Evoked Potential and Startle Response in the Rat
The P13 potential is the rodent equivalent of the P50 potential, which is an evoked response recorded at the vertex (Vx) 50 ms following an auditory stimulus in humans. Both the P13 and P50 potentials are only present during waking and rapid eye movement (REM) sleep, and are considered to be measures of level of arousal. The source of the P13 and P50 potentials appears to be the pedunculopontin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Brain research
دوره 884 1--2 شماره
صفحات -
تاریخ انتشار 2000